A rocky stream surrounded by trees and foliage.

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Our top choices for Cape Girardeau County hotels

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,000 reviews)
"The stay was great"
United States
Sandra
The price is CA $141
CA $159 total
includes taxes & fees
Sep 27 - Sep 28
Drury Plaza Hotel Cape Girardeau Conference Center

2. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (666 reviews)
"Very clean rooms, nice hotel."
United States
Alyssa
The price is CA $145
CA $163 total
includes taxes & fees
Sep 29 - Sep 30
The Riverview

3. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Good breakfast ( a bit crowded), roomy suite, good location, good value for a weekend stay"
United States
ELAINE
The price is CA $142
CA $162 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

4. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"Good location and reasonable prices"
Canada
Raidas
The price is CA $101
CA $114 total
includes taxes & fees
Sep 27 - Sep 28
Pear Tree Inn Cape Girardeau West

5. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Excellent full breakfast."
United States
Teresa
The price is CA $127
CA $143 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites Cape Girardeau

6. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,005 reviews)
"Great staff looks like a higher end hotel,great location great reception with drinks and soda fountain.breakfast good HOT TUB!Very clean smells good.Good shower"
United States
Thomas
The price is CA $120
CA $126 total
includes taxes & fees
Sep 27 - Sep 28
Drury Inn & Suites Jackson MO

7. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,001 reviews)
"Very enjoyable stay, great staff."
United States
Samuel
The price is CA $124
CA $147 total
includes taxes & fees
Oct 4 - Oct 5
Candlewood Suites Cape Girardeau by IHG

8. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (853 reviews)
"Clean, good location, comfortable beds"
United States
Elaine
The price is CA $124
CA $134 total
includes taxes & fees
Sep 28 - Sep 29
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

9. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.0 out of 10, Good, (799 reviews)
"No complaints"
United States
Danny
The price is CA $83
CA $94 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn Cape Girardeau North

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (229 reviews)
"Great hotel…!!"
United States
Carlos
The price is CA $142
CA $161 total
includes taxes & fees
Oct 1 - Oct 2
Fairfield Inn & Suites by Marriott Cape Girardeau

11. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (185 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is CA $126
CA $143 total
includes taxes & fees
Oct 4 - Oct 5
Tru By Hilton Cape Girardeau

12. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (551 reviews)
"Perfect place and location for our girls trip. The staff was excellent!"
United States
Kristin
The price is CA $182
CA $207 total
includes taxes & fees
Oct 4 - Oct 5
Courtyard by Marriott Cape Girardeau Downtown

13. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.2 out of 10, (239 reviews)
"Good atat"
United States
Joshua
The price is CA $105
CA $123 total
includes taxes & fees
Sep 24 - Sep 25
Town House Inn Cape Giradreau

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (847 reviews)
"Clean rooms and friendly staff"
United States
Rebekah
The price is CA $149
CA $168 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East

15. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2 out of 10, Very good, (781 reviews)
"Our room was clean and spacious. We had icy cold A/C and it was quiet there for the night!"
United States
VICTORIA
The price is CA $106
CA $115 total
includes taxes & fees
Oct 22 - Oct 23
Comfort Suites Jackson-Cape Girardeau

16. Town House Inn

Town House Inn
2.5 star property
Jackson
7.6 out of 10, Good, (447 reviews)
"Adequately comfortable "
United States
Taylor
The price is CA $91
CA $99 total
includes taxes & fees
Sep 24 - Sep 25
Town House Inn

17. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (58 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $114
CA $152 total
includes taxes & fees
Sep 24 - Sep 25
Little Blue Cottage on Spanish

18. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is CA $204
CA $296 total
includes taxes & fees
Sep 24 - Sep 25
The Little Cape Lofted Cottage | Creek & Nature

19. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is CA $197
CA $292 total
includes taxes & fees
Sep 24 - Sep 25
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

20. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (38 reviews)
"Amazing stay! Everything was perfect."
United States
Wayne F.
The price is CA $341
CA $536 total
includes taxes & fees
Oct 4 - Oct 5
The Twisted Sassafras Treehouse
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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